Ribosomal Protein L23 Negatively Regulates Cellular Apoptosis via the RPL23/Miz-1/C-Myc Circuit in Higher-Risk Myelodysplastic Syndrome
نویسندگان
چکیده
منابع مشابه
The Evolutionarily Conserved Ribosomal Protein L23 and the Cationic
Background: Reactive arthritis (ReA) is a T cell mediated inflammatory process. The immune response is primarily directed against a triggering organism, although autoimmunity has been invoked in long-lasting, antibiotic-resistant disease. Although a variety of different species are known to trigger Reactive arthritis, the clinical manifestations are strikingly similar as well as closely associa...
متن کاملReduced ribosomal protein gene dosage and p53 activation in low-risk myelodysplastic syndrome.
Reduced gene dosage of ribosomal protein subunits has been implicated in 5q- myelodysplastic syndrome and Diamond Blackfan anemia, but the cellular and pathophysiologic defects associated with these conditions are enigmatic. Using conditional inactivation of the ribosomal protein S6 gene in laboratory mice, we found that reduced ribosomal protein gene dosage recapitulates cardinal features of t...
متن کاملMYELOID NEOPLASIA Reduced ribosomal protein gene dosage and p53 activation in low-risk myelodysplastic syndrome
Departments of 1Genetics and 2Pathology, and 3Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA; 4Departments of Pathology and Clinical Laboratories, Memorial Sloan-Kettering Cancer Center, New York, NY; 5Department of Pediatrics, Stanford University, Stanford, CA; 6Department of Basic Medical Sciences, Purdue University, West Lafayette, IN; and 7Hudso...
متن کاملThe tumor suppressor protein HBP1 is a novel c-myc-binding protein that negatively regulates c-myc transcriptional activity.
c-Myc is an important transcription factor that regulates cellular proliferation, cell growth, and differentiation. A number of transcriptional co-factors for c-Myc have been described that have binding sites within highly conserved regions of the c-Myc transactivational domain (TAD). Given the importance of the c-Myc TAD, we set out to identify new proteins that interact with this region using...
متن کاملNucleostemin delays cellular senescence and negatively regulates TRF1 protein stability.
Nucleostemin (NS) encodes a nucleolar GTP-binding protein highly enriched in the stem cells and cancer cells. To determine its biological activity in vivo, we generated NS loss- and gain-of-function mouse models. The embryogenesis of homozygous NS-null (NS(-/-)) mice was aborted before the blastula stage. Although the growth and fertility of heterozygous NS-null (NS(+/-)) mice appeared normal, ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Leukemia Research
سال: 2017
ISSN: 0145-2126
DOI: 10.1016/s0145-2126(17)30279-5